Use of the plasma thrombin time to assess the adequacy of in vivo neutralization of heparin: comparative studies following operations employing extracorporeal circulation.
نویسندگان
چکیده
منابع مشابه
Comparing the Effects of Three Heparinization Methods of Hemodialysis Set on the Amount of Clot Formation during Hemodialysis
Background: Nowadays, the most important aspect of hemodialysis is the technical method of anticoagulation of extracorporeal circuit. This quasi-experimental study was performed to compare three methods of heparinization in the extracorporeal circulation. Methods: Twenty-seven hemodialysis patients referring to Rafsanjan Hemodialysis Center with the weight range of 50-90 kg and normal Clotting ...
متن کاملElevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass.
Patients who underwent operations in which cardiopulmonary bypass was used had elevations of plasma fibrinopeptide A which did not return to normal during bypass despite conventional heparin anticoagulation, suggesting inadequate heparin dosage and continued thrombin activity during the operation. Patients who underwent aortocoronary artery grafting had high plasma thromboxane B2 levels and a r...
متن کاملComparison of effects of protamine and polybrene, with special emphasis on the factor VIII (antihemophilic globulin) deficiency induced.
Successful achievement of extracorporeal circulation requires that blood coagulability be temporarily interrupted during perfusion and afterward restored to normal. Heparin is accepted as the drug of choice in rendering the blood incoagulable, but there are two drugs, protamine and Polybrene (hexadimethrine bromide), available for effective in vivo neutralization of heparin, and controversy exi...
متن کاملIn Vitro and in Vivo studies of the Effects of Cold Argon Plasma on Decreasing the Coagulation Time
Introduction Cold plasma is a self-sterilized, painless, and non-contact method in surgeries. These properties allow it to be applied to the living tissues and heat-sensitive parts. The aim of this study was to design a new cold plasma producer device and evaluate the effects of cold argon plasma on decreasing the coagulation time of blood drop in vitro and that of the injured liver blood in vi...
متن کاملProtamine sulfate down-regulates thrombin generation by inhibiting factor V activation.
Protamine sulfate is a positively charged polypeptide widely used to reverse heparin-induced anticoagulation. Paradoxically, prospective randomized trials have shown that protamine administration for heparin neutralization is associated with increased bleeding, particularly after cardiothoracic surgery with cardiopulmonary bypass. The molecular mechanism(s) through which protamine mediates this...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Blood
دوره 14 شماره
صفحات -
تاریخ انتشار 1959